Major study shows significant death risk reduction in type 2 diabetic
patients given a combined approach of blood pressure lowering and intensive
glucose control
Results presented at International Diabetes Federation Congress in Montreal
The results were presented yesterday by
The findings come from the ADVANCE (Action in Diabetes and Vascular Disease) trial, the largest-ever clinical trial of patients with type 2 diabetes, coordinated in
The new results presented yesterday suggest that the overall management of patients with established type 2 diabetes should incorporate routine blood pressure lowering and more intensive glucose control with the best care available to reduce the burden of further disease complications.
"These new findings of ADVANCE provide considerable reassurance that the widely used clinical approach of joint management of blood pressure and glucose in patients with type 2 diabetes is both appropriate and effective," said
The face of diabetes in
By 2010, more than 3 million Canadians will have diabetes and that number will continue to grow by nearly 550 every day. More than 60% of people with diabetes have high blood pressure, and almost 60% have high cholesterol. As a result, cardiovascular disease such as heart attacks and strokes is the leading cause of death in people with diabetes.
Key results
There was no interaction between the effects of the routine blood pressure lowering and intensive glucose control for any of the pre-specified clinical outcomes. When compared to neither intervention, combination treatment reduced the risk of new or worsening nephropathy by 33%, new onset macroalbuminuria by 54% and new onset microalbuminuria by 26%. Combination treatment was associated with an 18% reduction in the risk of all-cause death.
"We anticipate that the combined treatment strategy employed by ADVANCE may further reduce cardiovascular risk in the long term," said
About ADVANCE
ADVANCE (Action in Diabetes and Vascular Disease: Pretarax and Diamicron MR Controlled Evaluation) is a multi-centre, factorial randomized trial of perindopril-indapamide (Coversyl Plus) versus placebo and intensive glucose control with a gliclazide MR-based regimen (Diamicron MR) versus standard glucose control. The study involved more than 11,000 patients with type 2 diabetes and vascular disease studied in 215 centres in 20 countries, including 11 in
The ADVANCE trial was conducted by an independent collaborative group of medical researchers with support from the National Health & Medical Research Council of
About Centre hospitalier de l'Université de Montréal: www.chumontreal.qc.ca
About the Université de Montréal: www.med.umontreal.ca
For further information: Jonathan Gendron, HKDP Communications and Public Affairs, (418) 523-3352, ext. 222, [email protected]; Nathalie Forgue, Centre hospitalier de l'Université de Montréal, (514) 890-8000, ext. 14342; Sylvain-Jacques Desjardins, Université de Montréal, (514) 343-7593, [email protected]
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